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Vivian  Kahl


Current position:
Children’s Medical Research Institute – CMRI
02/2018- present Research Officer, Telomere Length Regulation Unit
Previous:
Commonwealth Scientific Research Orgsanisation – CSIRO (Adelaide, Australia)
2017- 2017 PhD overseas fellow. International supervisor: Michael Fenech, PhD
Lutheran University of Brazil – ULBRA (Canoas, Brazil)
2014 - 2017 PhD fellow. Supervisor: Juliana da Silva, PhD
2012 - 2014 Master’s fellow. Supervisor: Juliana da Silva, PhD
2007 - 2010 Undergraduate fellow. Supervisor: Juliana da Silva, PhD
Federal University of Rio Grande do Sul - UFRGS (Porto Alegre, Brazil)
2011 - 2011 Collaborator researcher. Supervisor: Katia Kvitko, PhD

Education
2014- 2018 PhD: Effect of occupational exposure to pesticides at tobacco fields: evaluation of molecular and cellular mechanisms through different methodologies.
Supervisor: Juliana da Silva, PhD.
Lutheran University of Brazil, ULBRA, Canoas, RS, Brazil
2012 – 2014 Master: Quantitative evaluation of telomere length in individuals occupationally exposed to pesticides.
Supervisor: Juliana da Silva, PhD.
Lutheran University of Brazil, ULBRA, Canoas, RS, Brazil

Grants Awarded
2018 Travel Award: Ian Potter Foundation for funding to attend the XIV Congress of the Brazilian Association of Mutagenesis and Environmental Genomics', Bento Gonçalves, Brazil, 3-6 June 2019. Granted by Ian Potter Foundation, Melbourne, Australia (AUD 2,000)
2017 Trainee Award: Public Notice for Doctoral Research as Visiting Student Scholarship as a PhD Visiting Student for 6 months. Granted by CAPES Foundation, Brasília, Brazil (AUD 15,593)
Commonwealth Scientific and Industrial Research Organization, CSIRO, Adelaide, Australia
2016 MutaGen-ALAMCTA Contest: Travel support for the X Conference of the Latin American Association of Environmental Mutagenesis, Carcinogenesis and Teratogenesis (X ALAMCTA). Granted by Mutagen, Brazilian Association of Environmental Mutagenesis and Genomics (AUD 500).
Title of the short communication awarded: The influence of pesticides and nicotine on telomere length maintenance in tobacco farmers.
X ALAMCTA. October 13th to 16th, 2016. Montevideo, Uruguay.
2014 Trainee Award: Public Notice for the Internationalization of Postgraduate Programs from Rio Grande do Sul. Granted by Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS), RS, Brazil (AUD 39,400).
Internship in Training in Cytogenetic-Molecular Methods (workload: 180h)
Commonwealth Scientific and Industrial Research Organization, CSIRO, Adelaide, Australia

Publications
Peer review journals
1. Fernandes, S.; Kvitko, K.; da Silva, J.; Rohr, P.; Bandinelli, E.; KAHL, V.F.S.; Mai, C.; Brenner, N.; da Silva, F. Influence of vitamin intake and MTHFR polymorphism on the levels of DNA damage in tobacco farmers. International Journal of Occupational and Environmental Health. 2018. DOI: 10.1080/10773525.2018.1500796.
2. KAHL, V.F.S.; Dhillon, V.S.; Fenech, M.; de Souza, M.R.; da Silva, F.N.; Marroni, N.A.P.; Nunes, E.A.; Cerchiaro, G.; Pedron, T.; Batista, B.L.; Cappetta, M.; Martinez-Lopez, W.; Simon, D.; Da Silva, J. Occupational exposure to pesticides in tobacco fields: the integrated evaluation of nutritional intake and susceptibility on genomic and epigenetic instability. Oxidative Medicine and Cellular Longevity. p. 7017423, 2018. DOI: 10.1155/2018/7017423.
3. KAHL, V.F.S.; da Silva, F.R.; Alves, J.S.; da Silva, G.F.; Piccinini, J.; Dhillon, V.S.; Fenech, M.; de Souza, M.R.; Dias, J.F.; de Souza, C.T.; Salvador, M.; Branco, C.S.; Thiesen, F.V.; Simon, D.; Da Silva, J. Role of
PON1, SOD2, OGG1, XRCC1 and XRCC4 polymorphisms on modulation of DNA damage in workers occupationally exposed to pesticides. Ecotoxicology and Environmental Safety. v. 159, p. 164-171, 2018. DOI: 10.1016/j.ecoenv.2018.04.052
4. KAHL, V.F.S.; Dhillon, V.S.; Simon, D.; Silva, F.R.; Salvador, M.; Branco, C.; Cappetta, M.; Martinez-Lopez, W.; Thiesen, F.V.; Dias, J.F.; de Souza, C.T.; Fenech, M.; Da Silva, J. Chronic occupational exposure endured by tobacco farmers from Brazil and association with DNA damage. Mutagenesis. v. 33, p. 119-128, 2018. DOI: doi.org/10.1093/mutage/gex045
5. KAHL, V.F.S.; Simon, D.; Souza, M.R.; Vieira, H.R.; Nicolau, C.; Da Silva, F.R.; Kvitko, K.; Peres, A.; Dorneles, G.P.; de Souza, C.T.; Dias, J.F.; Da Silva, J. Base excision repair (OGG1 and XRCC1) and metabolism (PON1) gene polymorphisms act on modulation of DNA damage and immune parameters in tobacco farmers. Mutation Research – Genetic Toxicology and Environmental Mutagenesis. 2018. DOI: https://doi.org/10.1016/j.mrgentox.2018.04.001.
6. De Souza, M.R.; KAHL, V.F.S.; Rohr, P.; Kvitko, K.; Cappetta, M.; Martinez-Lopez, W.; Da Silva, J. Shorter telomere length and DNA hypermethylation in peripheral blood cells of coal workers. Mutation Research – Genetic Toxicology and Environmental Mutagenesis. 2018. DOI: 10.1016/j.mrgentox.2018.03.009.
7. KAHL, V.F.S.; da Silva, F.R.; Alves, J.S.; da Silva, G.F.; Picinini, J.; Dhillon, V.S.; Fenech, M.; de Souza, M.R.; Dias, J.F.; de Souza, C.T.; Salvador, M.; Branco, C.S.; Thiesen, F.V.; Simon, D.; Da Silva, J. Role of PON1, SOD2, OGG1, XRCC1, and XRCC4 polymorphisms on modulation of DNA damage in workers occupationally exposed to pesticides. Ecotoxicology and Environmental Safety. v. 159, p. 164-171, 2018. DOI: 10.1016/j.ecoenv.2018.04.052.
8. KAHL, V. F. S.; Simon, D.; Salvador, M.; Branco, C.; Dias, J. F.; Da Silva, F.R.; Souza, C. T.; da Silva, J. Telomere measurement in individuals occupationally exposed to pesticide mixtures in tobacco fields. Environmental and Molecular Mutagenesis. v.57, p.74 - 84, 2016. DOI: 10.1002/em.21984
9. KAHL, V.F.S.; Da Silva, J.; Da Silva, F.R. Influence of exposure to pesticides on telomere length in tobacco farmers: a biology system approach. Mutation Research. v.791-792, p. 19-26, 2016. DOI: 10.1016/j.mrfmmm.2016.08.003.
10. Nunes, R. S.; KAHL, V. F. S.; Sarmento, M. S.; Nunes, M. F. S.; Porto, C. R. M.; Andrade, V.; Ferraz, A. F. B.; Da Silva, J. Protective effects of acerola juice on genotoxicity induced by iron in vivo. Genetics and Molecular Biology. v.39, p.122 - 128, 2016. DOI: 10.1590/1678-4685-GMB-2015-0157
11. KAHL, V. F. S.; Fenech, M.; Simon, D.; da Silva, J. Telomere length: what it could tell us?. Applied Research in Toxicology. v.1, p.46 - 47, 2015.
12. Nunes, M.F.S.; Nunes, R.S.; KAHL, V.F.S.; Reyes, J.M.; Da Silva, J. Use of Buccal Micronucleus Assay to Determine Mutagenicity Induced by Amfepramone in Humans and the Protective Effects of Vitamin C. Journal of Toxicology and Environmental Health. Part A. v.76, p.1121 - 1128, 2013. DOI: 10.1080/15287394.2013.841533
13. Da Silva, F.R; da Silva, J.; Nunes, E.; Benedetti, D.; KAHL, V. F. S.; Rohr, P.; Abreu, M.B.; Thiesen, F.V.; Kvitko, K. Application of the buccal micronucleus cytome assay and analysis of PON1Gln192Arg and CYP2A6*9(-48T>G) polymorphisms in tobacco farmers. Environmental and Molecular Mutagenesis. v.53, p.525 - 534, 2012. DOI: 10.1002/em.21713
14. Nunes, R.S.; KAHL, V.F.S.; Sarmento, M.S.; Richter, M.F.; Abin-Carriquiry, J.A.; Martinez, M.M.; Ferraz, A.B.F.; da Silva, Juliana. Genotoxic and Antigenotoxic Activity of Acerola (Malpighia glabra L.) Extract in Relation to the Geographic Origin. Phytotherapy Research. v.10, p.n/a - n/a, 2012. DOI: 10.1002/ptr.4896
15. Da Silva, F.R.; da Silva, J.; Allgayer, M.C.; Simon, C.F.; Dias, J.F.; dos Santos, C.E.I.; Salvador, M.; Branco, C.; Schneider, N.B.; KAHL, V.F.S.; Rohr, P.; Kvitko, K. Genotoxic biomonitoring of tobacco farmers: Biomarkers of exposure, of early biological effects and of susceptibility. Journal of Hazardous Materials. v.225-226, p.81 - 90, 2012. DOI: 10.1016/j.jhazmat.2012.04.074
16. KAHL, V.F.S.; Reyes, J.M.; Sarmento, M.S.; da Silva, J. Mitigation by vitamin C of the genotoxic effects of nicotine in mice, assessed by the comet assay and micronucleus induction. Mutation Research. Genetic Toxicology and Environmental Mutagenesis. v.744, p.140 - 144, 2012. DOI: 10.1016/j.mrgentox.2012.01.008
17. Nunes, R.S.; KAHL, V.F.S.; Sarmento, M.S.; Richter, M.F.; Costa-Lotufo, L.V.; Rodrigues, F.A. R.; Abin-Carriquiry, J.; Martinez, M.M.; Ferronato, S.; Ferraz, A.B.F.; Silva, J. Antigenotoxicity and Antioxidant Activity of Acerola Fruit (Malpighia glabra L.) at Two Stages of Ripeness. Plant Foods for Human Nutrition. v.66, p.129 - 135, 2011. DOI: 10.1007/s11130-011-0223-7
18. Kaefer, V.; Semedo, J.G.; KAHL, V.F.S.; Von Borowsky, R.G.; Gianesini, J.; Kist, T.B.L.; Pereira, P.; Picada, J.N. DNA damage in brain cells and behavioral deficits in mice after treatment with high doses of amantadine. Journal of Applied Toxicology. v.30, p.745 - 753, 2010. DOI: 10.1002/jat.1550
19. Pereira, P.; Gianesini, J.; Barbosa, C.S.; Cassol, G.; Von Borowski, R.; KAHL, V.F.S.; Cappelari, S.; Picada, J.N. Neurobehavioral and genotoxic parameters of duloxetine in mice using the inhibitory avoidance task and comet assay as experimental models. Pharmacological Research. v.59, p.57 - 61, 2009. DOI: 10.1016/j.phrs.2008.09.014

Chapters of books
1. KAHL, V.F.S.; DA SILVA, J. Telomere length and its relation to human health. In: Telomere: a Complex End of a Chromosome. Marcelo L. Larramendy (Ed.) 1 ed. Croatia: InTech Open, 2016, p163-186.
2. SILVA, J.; PRA, D.; KAHL, V; NUNES, M. F. S.; NUNES, R. S.; ANDRADE, V.; LEFFA, D.; FRANKE, S. I. R. Vitamin C Supplementation: Favorable or Noxious? In: Vitamin C: Dietary Sources, Technology, Daily Requirements and Symptoms of Deficiency.1 ed.Hauppauge, NY : Nova Publishers, 2013, p7-20.

Accepted chapter of book
1. KAHL, V.F.S.; Garcia, A.L.H.; de Souza, M.R.; Dalberto, D.; Oliveira, A.F.B.; Da Silva, J. Biomarkers of early effects for occupational exposure. In: Occupational Stress: Risk Factors, Prevention and Management Strategies. Nicola Mucci (Ed.) 1 ed. USA: Nova Publishers, 2018.
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